![]() ![]() Olympus IX81 fluorescent microscope equiped with MicroPublisher 3.3 RTV camera.FACSAria III (Becton Dickinson) fluorescence-activated cell sorting system.CFX384 Real Time System (BioRad) for gene expression analysis on 384 well plates.Water purification system Simplicity UV (Merk).Development of novel stem cell- and EV-based advanced therapy medicinal products (ATMPs) for their use in treatment of patients with civilization diseases (preclinical and clinical studies).Optimization of biocompatible scaffolds combining biomaterials (including graphene) and defined stem cell populations for tissue regeneration. ![]() Role of stem cell derived extracellular vesicles (native and genetically modified) in tissue.Optimization of procedures for various stem cell and EV fractions identification and isolation for their use in regenerative medicine.Applications of stem cells and stem cell derived extracellular vesicles (EVs) in regenerative medicine.Optimization of stem cell and progenitor cell populations for applications in experimental cardiology and orthopedy including induced pluripotent stem cells (iPSCs) as well as mesenchymal stem cells (MSCs) of different antigenic phenotype various types.Tissue skin engineering – reconstruction of three-dimensional connective tissue equivalents using mesenchymal stem cells.Application of in vitro skin cell cultures in clinical practice, such as wound treatment and plastic surgery.The use of advanced cell culture techniques (cell cultures at the air-liquid interface in the ALI model epithelial-mesenchymal trophic unit EMTU - co-cultures of epithelial cells with fibroblasts) in the study of respiratory and skin diseases.The effect of selected compounds from the chalcone family on the inhibition of pro-fibrotic changes in selected diseases.Mechanisms of bronchial / lung cell interactions within epithelial-mesenchymal trophic unit.Fibroblast to myofibroblast transition (FMT) mechanisms and role of FMT in bronchial wall remodeling in asthma searching for and testing the selected compounds affecting the FMT efficiency with possible therapeutic potential.Effect of phytoactive compounds on cancer drug-resistance.Cancer stem cells, drug-resistance and combined strategies of cancer treatment.Mechanisms of epithelial–mesenchymal transition (EMT) and its interrelations with cancer stem cells and metabolic elasticity of cancer cells. ![]() Involvement of connexins and cell adhesion molecules in the regulation of cancer cells' invasiveness.Application of electrochemical methods in cell biology. ![]()
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